HORDB

ID: hor005301
Uniprot ID: P68004
Protein name: Peptide YY
Gene name: PYY
Organism: Canis lupus familiaris (Dog) (Canis familiaris)
Family: NPY family
Source: animal
Expression: NA
Disease: NA
Comments: NA
Taxonomy: Canis lupus (species), Canis (genus), Canidae (family), Caniformia (suborder), Carnivora (order), Laurasiatheria (superorder), Boreoeutheria, Eutheria, Theria, Mammalia (class), Amniota, Tetrapoda, Dipnotetrapodomorpha, Sarcopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
GO MF: GO:0005179 hormone activity; GO:0031841 neuropeptide Y receptor binding
GO BP: GO:0007165 signal transduction
GO CC: GO:0005576 extracellular region

Function: This gut peptide inhibits exocrine pancreatic secretion, has a vasoconstrictory action and inhibitis jejunal and colonic mobility.
Mechanism: NA
Cross BBB: NO
Target: NA
Target Unid: NA
IC50: NA
EC50: NA
ED50: NA
kd: NA
Half life: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

AF-P68004-F1.pdb

hor005301_AF2.pdb

hor005301_ESM.pdb

Mass:	486613	Formula:	C190H287N53O58
Absent amino acids:	CFIMW	Common amino acids:	Y
pI:	7.52	Basic residues:	6
Polar residues:	11	Hydrophobic residues:	9
Hydrophobicity:	-109.44	Boman Index:	-9960
Half-Life:	2.8 hour	Half-Life Yeast:	10 min
Half-Life E.Coli:	2 min	Aliphatic Index	62.5
Instability Index:	9299.17	Extinction Coefficient cystines:	7450
Absorbance 280nm:	212.86